A 2-dimensional computational model to analyze the effects of cellular heterogeinity on cardiac pacemaking

Campana, Chiara (2015) A 2-dimensional computational model to analyze the effects of cellular heterogeinity on cardiac pacemaking. [Laurea magistrale], Università di Bologna, Corso di Studio in Ingegneria biomedica [LM-DM270] - Cesena
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Abstract

The mechanical action of the heart is made possible in response to electrical events that involve the cardiac cells, a property that classifies the heart tissue between the excitable tissues. At the cellular level, the electrical event is the signal that triggers the mechanical contraction, inducing a transient increase in intracellular calcium which, in turn, carries the message of contraction to the contractile proteins of the cell. The primary goal of my project was to implement in CUDA (Compute Unified Device Architecture, an hardware architecture for parallel processing created by NVIDIA) a tissue model of the rabbit sinoatrial node to evaluate the heterogeneity of its structure and how that variability influences the behavior of the cells. In particular, each cell has an intrinsic discharge frequency, thus different from that of every other cell of the tissue and it is interesting to study the process of synchronization of the cells and look at the value of the last discharge frequency if they synchronized.

Abstract
Tipologia del documento
Tesi di laurea (Laurea magistrale)
Autore della tesi
Campana, Chiara
Relatore della tesi
Correlatore della tesi
Scuola
Corso di studio
Ordinamento Cds
DM270
Parole chiave
mathematical, modeling, sinoatrial, node, cardiac, computational, model, heterogeneity, electrophysiology
Data di discussione della Tesi
19 Marzo 2015
URI

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