Complessi Rutenio-FANS, sintesi e strutture

Cancer certainly constitutes one of the main medical and social issues, which has received lots of efforts from the scientific community, especially researching new metallodrugs, exhibiting enhanced efficacy (related to dose-response relationship) and by reducing the adverse collateral effects against the integer cells. In the context, we select a dihydride Ruthenium complex to anchor several different NSAIDs (non-steroidal anti-inflammatory drugs) by prompt realising of molecular H2 through thermal solicitation in satisfying yield. The optimized syntheses allow complete characterization by Ms-ESI, IR, multinuclear 1H, 13C{1H} 31P NMR and UV-Vis. Further two of the obtained species gave crystals suitable for X-ray diffraction studies. As future perspectives we plan to test the moisture-unsensitive and stable Ru-compounds as potential antibacterial, antifungal or anticancer drugs, in collaboration with the Biologists of the Unibo Department.