Studio della reazione di Friedlander atroposelettiva

The aim of this thesis work is to develop and optimize a new strategy of atroposelective synthesis to obtain the 2-methyl-4- (naphthalen-1-yl) quinolin-3-ol substrate. It was decided to start from a well known process for obtaining this product, namely the Friedländer synthesis using a chiral Brønsted acid as catalyst. The different physiological activities and the antimalarial properties of this type of heterocyclic compound together with its applications in various fields of chemistry as well as pharmaceutical are some of the reasons why it was decided to undertake this research work. Given the importance of the characteristics mentioned above, in the last decades numerous methods have been developed for their synthesis, but enantioselective versions are still few in the literature. Furthermore, with the emergence of a less common form of chirality, such as axial, the demand for new synthetic pathways has become even more complex. In the light of the state of art in this project there is also the desire to enrich the scenario of chemical research with the presentation of a new synthetic enantioselective path to obtain atropisomeric products.