Design e sintesi di nuove sonde luminescenti per il "targeting" dell'avidina

Vaccari, Maria Chiara (2013) Design e sintesi di nuove sonde luminescenti per il "targeting" dell'avidina. [Laurea magistrale], Università di Bologna, Corso di Studio in Chimica industriale [LM-DM270]
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Recent studies on the use of bio-conjugating organometallic probes report on the possibility to use biotinylated-derivatives to selectively coordinate to a specific protein, avidin. In the present thesis, the synthesis of four new bifunctional ligands is described. The ligands contain both a pyridine triazolic unit able to coordinate a transition metal, and a biotin fragment able to bond avidin: the two functionalities are linked together by an appropriate aromatic linker (amide or ester). The obtained ligands were then employed to form luminescent Ir(III) complexes, that have been fully characterized also by a photophysical point of view both in organic and in aqueous solvent. Therefore, titrations of solutions of avidin with aqueous solutions of Ir(III)-complexes have been performed in order to estimate the luminescence variations of the complexes in the presence or in the absence of bio-conjugation.

Tipologia del documento
Tesi di laurea (Laurea magistrale)
Autore della tesi
Vaccari, Maria Chiara
Relatore della tesi
Correlatore della tesi
Corso di studio
Ordinamento Cds
Parole chiave
Avidina, Biotina, bioconiugazione, complessi luminescenti, Iridio(III)
Data di discussione della Tesi
8 Marzo 2013

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