The study of Lovastatin production as a benchmark simulation model for bio-manufacturing processes

Perra, Simone (2020) The study of Lovastatin production as a benchmark simulation model for bio-manufacturing processes. [Laurea magistrale], Università di Bologna, Corso di Studio in Ingegneria chimica e di processo [LM-DM270], Documento full-text non disponibile
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In this work an end to end bio-pharmaceutical process for the production of lovastatin is implemented into a Matlab/Simulink environment. The simulation is developed with the objective to be a generic reference model, as it captures the typical dynamics of pharmaceutical bio-manufacturing. It can then be used as an open-source test problem to study different process scenarios in dynamic mode. The objective of this work is to propose the benchmark simulation as a testbed for the development and comparison of different control strategies in dynamic mode. To this purpose a highly referenced control framework (the Skogestad method) is adapted and applied to the dynamics of the present model. The implemented framework includes a distributed control system (DCS) as regulatory control layer, and an MPC multiple-input multiple-output application as a supervisory control layer. As an alternative for the supervisory control layer, an override control framework based on process knowledge is developed and validated as a lighter solution. The different control setups are compared from a total productivity and stability point of view in a set of case-studies. As expected, the MPC application is the most stable solution, but in all the case studies the alternative override supervisory control gives comparable API final productivity. Pharmaceutical bio-manufacturing is a highly regulated industry in which the resources and time dedicated to process optimization and control are limited. The development of an end to end reference simulation with a limited number of unit operations is a step towards a smarter resource exploitation in the industry.

Tipologia del documento
Tesi di laurea (Laurea magistrale)
Autore della tesi
Perra, Simone
Relatore della tesi
Correlatore della tesi
Corso di studio
Sustainable technologies and biotechnologies for energy and materials
Ordinamento Cds
Parole chiave
Data di discussione della Tesi
13 Marzo 2020

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