Influence of free-radical functionalization on non-woven filtering media for medical application

Albertini, Edoardo (2019) Influence of free-radical functionalization on non-woven filtering media for medical application. [Laurea magistrale], Università di Bologna, Corso di Studio in Chimica industriale [LM-DM270]
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Nowadays the leukodepletion is one of the most important processes done on the blood in order to reduce the risk of transfusion diseases. It can be performed through different techniques but the most popular one is the filtration due to its simplicity and efficiency. This work aims at improving a current commercial product, by developing a new filter based on Fenton-type reaction to cross-link a hydrogel on to the base material. The filters for leukodepletion are preferably made through the melt flow technique resulting in a non-woven tissue; the functionalization should increase the stability of the filter restricting the extraction of substances to minimum amount when in contact with blood. Through the modification the filters can acquire new properties including wettability, surface charge and good resistance to the extractions. The most important for leukodepletion is the surface charge due to the nature of the filtration process. All the modified samples results have been compared to the commercial product. Three different polymers (A, B and C) have been studied for the filter modifications and every modified filter has been tested in order to determine its properties.

Tipologia del documento
Tesi di laurea (Laurea magistrale)
Autore della tesi
Albertini, Edoardo
Relatore della tesi
Correlatore della tesi
Corso di studio
Ordinamento Cds
Parole chiave
leukodepletion non-woven filter free-radical functionalization surface charge
Data di discussione della Tesi
25 Ottobre 2019

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