Sinthesys of heteroleptic zinc complexes for imaging in living cells

Tabone, Roberta (2019) Sinthesys of heteroleptic zinc complexes for imaging in living cells. [Laurea magistrale], Università di Bologna, Corso di Studio in Chimica industriale [LM-DM270]
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This thesis arose from an interest in luminescence heteroleptic bis(dipyrrinato) Zn (II) complexes and their application in cell imaging, due to their attractive and fascinating characteristics. Among imaging technologies, near-infrared fluorescence imaging has been dedicated immense attention owing to its low absorption and autofluorescence from surrounding organism and tissues in this specific spectral region, which minimize background interference and improve tissue depth penetration. An ideal near-infrared probe should be equipped with excellence chemical and photophysical properties. The target of this work is the synthesis of new heteroleptic bis(dipyrrinato) Zn (II) complexes having two main features: the emission in the near-infrared region and water-solubility. In order to purse these intentions, the low-energy emission was achieved by expansion of π-conjugation of simple dipyrrins using Knoevenagel condensation106 and tri(ethylene)glycol chain was introduced to increase the water solubility of the final complex. Photophysical and luminescent properties of the new complexes were investigated. Finally, with a view to a potential biological use of these new complexes in biological environments, their biocompatibility was tested using a cell viability assay: (3-(4,5-dimethylthiazol-2-yl)-2’-5’-diphenyltetrazolium bromide (MTT) assay.

Tipologia del documento
Tesi di laurea (Laurea magistrale)
Autore della tesi
Tabone, Roberta
Relatore della tesi
Correlatore della tesi
Corso di studio
Ordinamento Cds
Parole chiave
imaging cells heteroleptic zinc complexes luminescence fluorescence biocompatibility synthesis bis(dipyrrinato) NIR Nir probes
Data di discussione della Tesi
25 Ottobre 2019

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