Comparison of radiobiological effects induced by ultra-high and standard dose rate of x-rays on a radio-resistant cell line

Petrigliano, Maria Stefania (2016) Comparison of radiobiological effects induced by ultra-high and standard dose rate of x-rays on a radio-resistant cell line. [Laurea magistrale], Università di Bologna, Corso di Studio in Fisica [LM-DM270]
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Abstract

Radiotherapy (RT) has recently evolved with the emergence of heavy ion radiations or new fractionation schemes of photon therapy, which modify the dose rate of treatment delivery. The aim of the present study was then to evaluate the in vitro influence of a ultra-high dose rate comparing them with standard dose rate. In this regard, a radioresistant SK-MEL-28 cell line were irradiated with x-ray in order to have a total dose of 2 and 4 Gy, at two different dose rate. The ultra-high dose rate is a specific property of the dense plasma focus (DPF) device, which has pulsed operation and thus gives short and highly energetic pulses of multiple types of rays and particles, in this case, we focused our study on the influence of X-rays. While a low dose rate is obtained with conventional X-ray tube. In this study it results that a ultra-high dose rate enhances radiosensitivity of melanoma cells while reducing the adhesion, proliferation and migration ability of cells.

Abstract
Tipologia del documento
Tesi di laurea (Laurea magistrale)
Autore della tesi
Petrigliano, Maria Stefania
Relatore della tesi
Correlatore della tesi
Scuola
Corso di studio
Indirizzo
Curriculum E: Fisica applicata
Ordinamento Cds
DM270
Parole chiave
Plasma Focus
Data di discussione della Tesi
22 Luglio 2016
URI

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