Finite element modeling of flow/compression-induced deformation of alginate scaffolds for bone tissue engineering

Tegas, Antonio Vasile (2016) Finite element modeling of flow/compression-induced deformation of alginate scaffolds for bone tissue engineering. [Laurea magistrale], Università di Bologna, Corso di Studio in Ingegneria biomedica [LM-DM270] - Cesena
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Trauma or degenerative diseases such as osteonecrosis may determine bone loss whose recover is promised by a "tissue engineering“ approach. This strategy involves the use of stem cells, grown onboard of adequate biocompatible/bioreabsorbable hosting templates (usually defined as scaffolds) and cultured in specific dynamic environments afforded by differentiation-inducing actuators (usually defined as bioreactors) to produce implantable tissue constructs. The purpose of this thesis is to evaluate, by finite element modeling of flow/compression-induced deformation, alginate scaffolds intended for bone tissue engineering. This work was conducted at the Biomechanics Laboratory of the Institute of Biomedical and Neural Engineering of the Reykjavik University of Iceland. In this respect, Comsol Multiphysics 5.1 simulations were carried out to approximate the loads over alginate 3D matrices under perfusion, compression and perfusion+compression, when varyingalginate pore size and flow/compression regimen. The results of the simulations show that the shear forces in the matrix of the scaffold increase coherently with the increase in flow and load, and decrease with the increase of the pore size. Flow and load rates suggested for proper osteogenic cell differentiation are reported.

Tipologia del documento
Tesi di laurea (Laurea magistrale)
Autore della tesi
Tegas, Antonio Vasile
Relatore della tesi
Correlatore della tesi
Corso di studio
Ordinamento Cds
Parole chiave
tissue engineering bone stem cells bioreactors finite element modeling Institute of Biomedical and Neural Engineering alginate collagen perfusion compression differentiation-inducing
Data di discussione della Tesi
17 Marzo 2016

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