Chimica di complessi di rutenio con leganti basi di Schiff chelanti

The present experimental thesis describes the synthesis and characterization of novel Ruthenium organometallic complexes, coordinating biocompatible p-extended polydentate ligands Schiff base ligands with substituents as pyrrole, indole, phenyl or phenolic groups, showing potential pharmacological applications as anticancer or antimicrobial activity. The work focuses on the design and optimization of the synthetic procedures which allow stability in biological conditions and the control over their chemical and potential biological effectiveness. The complex structures were validated by ESI-MS, IR, NMR, and UV-Vis spectroscopy, particularly concerning their stability in PBS (Phosphate Buffer Solution) physiological solutions, simulating biological conditions. The results highlighted that Ruthenium complexes with bidentate or tridentate ligands present promising features for the use in pharmaceutical field, thanks to their ability to effectively coordinate to the metal center maintaining the stability in physiological environments.