Composites based on Zinc Imidazolate Frameworks (ZIF-8) for biomedical applications

The aim of this thesis was the synthesis and characterization of composite materials with antibacterial properties, through the deposition of ZIF-8 (Zeolitic Imidazolate Framework), a subclass of MOFs (Metal Organic Frameworks). The synthesis of the coordination compound was carried out at room temperature, with ultrapure water (H2OmQ) as solvent and using Zn(OAc)2∙2H2O and 2-Methylimidazole (2-HmIM) as reagents. In the research group where I carried out my internship, the optimization of the synthetic process led to the definition of an optimal molar ratio between the reagents Zn:2-HmIM of 1:10 or 1:16, depending on the type of support, to obtain the crystalline structure with the highest surface area (sodalite structure). Most of my internship work has been dedicated to the functionalization of the following supports. 1. Titanium scaffolds: to create prostheses that reduce infection risks and promote cellular regeneration processes, enhancing osteoblast activity over time. This work is carried out in collaboration with Prof. Elisa Mazzoni’s group, University of Ferrara and Prof. Silvia Panzavolta’s group, Department of Chemistry “Giacomo Ciamician”, University of Bologna. 2. Hydrogels: to create a biocomposite material able to promote the healing of infected tissues, and compare the properties obtained with the cellulose-based biocomposite. 3. Paper supports: to protect cultural heritage assets (such as historical books) from biodegradation by bacteria and fungi. This work is carried out in collaboration with Prof. Elisabetta Zendri’s Group, Department of Environmental Sciences, Informatics and Statistics, University of Venice. Furthermore, I also took part in the research project involving the encapsulation of snail slime in the ZIF-8 structure for the preparation of a hybrid system that exploits the therapeutic properties of both components.