Left atrium fibrosis quantification in atrial fibrillation patients: an open issue

Berrettini, Vittoria (2023) Left atrium fibrosis quantification in atrial fibrillation patients: an open issue. [Laurea magistrale], Università di Bologna, Corso di Studio in Biomedical engineering [LM-DM270] - Cesena, Documento full-text non disponibile
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Abstract

Atrial fibrillation is the most common arrhythmia and its incidence is expected to increase due to population ageing. This disease is related to an increased risk of stroke, thromboembolism, cardiac arrest, dementia and mortality. Atrial fibrillation is associated with electrical, contractile and structural remodeling in the left atrium and it is sustained by the co-presence of an arrhythmogenic trigger and a proarrhythmic substrate. One of the main mechanisms that contribute to this process is atrial fibrosis. Detection and quantification of fibrotic tissue are possible using late gadolinium enhanced magnetic resonance imaging (LGE-MRI). Quantification of fibrosis burden through this technique could be helpful in predicting the outcome of ablation, allowing the selection of patients that could undergo the procedure. The main problem is represented by the lack of a standardized and reproducible method to locate and quantify fibrosis in left atrium. The main aim of this thesis is to evaluate different algorithms, which have been proposed in literature, to quantify left atrium fibrosis in atrial fibrillation patients, implementing and testing them on a dataset of patients. The algorithms that have been analysed are histogram-based reference, histogram-based reference with dynamic thresholding approach, nulled myocardium-based reference, blood pool-based reference, full width at half maximum, maximum scar density percentage and image intensity ratio.

Abstract
Tipologia del documento
Tesi di laurea (Laurea magistrale)
Autore della tesi
Berrettini, Vittoria
Relatore della tesi
Correlatore della tesi
Scuola
Corso di studio
Indirizzo
CURRICULUM INNOVATIVE TECHNOLOGIES IN DIAGNOSTICS AND THERAPY
Ordinamento Cds
DM270
Parole chiave
Atrial fibrillation,Atrial fibrosis,Left atrium,Late gadolinium enhancement,Magnetic resonance imaging
Data di discussione della Tesi
16 Marzo 2023
URI

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