Study of the activity and enantioselectivity of alginate-based catalysts in Friedel-Crafts reactions

Soccio, Alberto (2022) Study of the activity and enantioselectivity of alginate-based catalysts in Friedel-Crafts reactions. [Laurea magistrale], Università di Bologna, Corso di Studio in Low carbon technologies and sustainable chemistry [LM-DM270]
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Abstract

This thesis is part of a long-term project which aims to demonstrate for the first time that alginate gel beads can be used as chiral heterogeneous catalysts for enantioselective reactions. Alginate barium beads were prepared as previously optimized and applied to the Friedel-Crafts reaction between indoles and nitroalkenes. New substrates were tested, showing that the reaction can accommodate different nitroalkenes and indoles, affording the corresponding products with moderate yields and good enantioselectivities. However, aliphatic nitroalkenes cannot be used as they degrade under the catalytic reaction conditions. Preliminary study on the recyclability of the heterogeneous catalyst indicated a moderate stability of the catalyst, which can be used for few cycles with a slight erosion of enantioinducing power. Some directions for future improvements (storage and work-up solvent, use of ultrasonic bath) have been suggested.

Abstract
Tipologia del documento
Tesi di laurea (Laurea magistrale)
Autore della tesi
Soccio, Alberto
Relatore della tesi
Scuola
Corso di studio
Ordinamento Cds
DM270
Parole chiave
alginates enantioselection Friedel-Crafts alkylation Henry reaction recyclability
Data di discussione della Tesi
21 Ottobre 2022
URI

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