Finite element study of fractured mandible in human and sheep

Osteosynthesis is one of the most discussed and investigated subjects in the orthopaedic literature. Mandible fractures are reported as one of the main causes of facial injury and their impact on patient life may bring serious consequences, compromising masticatory function, speech and facial aesthetics. Current treatments for mandibular simple fractures include the use of load-sharing devices such as titanium miniplates and screws, which have the role of fixing the fracture ends and restore the facial continuity. Fixation systems ultimately aim to generate the optimum mechanical strains within the fracture region, which will promote the bone healing process. However, there is not a clear understanding of the influence of fixation stability on the biomechanics of stabilized mandibular fractures, particularly when using biomaterials different from titanium. The aim of this study is to investigate the biomechanical response of fractured mandible using traditional titanium miniplates and alternative fixation systems made of magnesium alloys. With a view on future preclinical evaluation of these new devices, both human and sheep models are investigated.