Nuova strategia di sintesi metal-free di substrati arilamminici

Arylamines are a class of compounds whose importance in chemical and pharmaceutical fields has been consolidated over time. With the increasing use of these Active Pharmaceutical Ingredients (APIs), many synthesis techniques have been created since the 1990s to obtain these products. The most well-known arylamines synthesis techniques to date are all catalyzed metal reactions. Chronologically, the synthesis changed from the use of cross coupling reactions such as Buchwald-Hartwig or Chan-Evans-Lam, to oxidative reactions in the presence of noble metals. The aim of this project was to outline a new synthetic strategy to obtain arylamine substrates, thus avoiding the use of catalysts made by noble metals. The reaction was discovered accidentally following an experimental evidence, since a by-product different was obtained. The main purpose of the thesis was to optimize the following reaction to obtain a high yield and in the meantime try to understand how the particular structure of substrate could be fundamental to allow the aromatization of the molecule.